Intended for licensed healthcare professionals located in the United Kingdom only.

About
PEMAZYRE

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About PEMAZYRE® (pemigatinib)

DNA Helix

PEMAZYRE monotherapy is indicated for the treatment of adults with locally advanced or metastatic cholangiocarcinoma (CCA) with a fibroblast growth factor receptor 2 (FGFR2) fusion or rearrangement that have progressed after at least one prior line of systemic therapy. Contraindications for use include hypersensitivity to the active substance or excipients and concomitant use with St Johns’ wort.

Pemigatinib is a kinase inhibitor of FGFR1, 2 and 3. It inhibits FGFR phosphorylation and signalling, and decreases cell viability in cells expressing FGFR genetic alterations, including point mutations, amplifications, and fusions or rearrangements.

FGFR fusion positivity status must be known prior to initiation of PEMAZYRE therapy. Assessment for FGFR2 fusion positivity in tumour specimens should be performed with an appropriate diagnostic test.

Mechanism of action of pemigatinib

Pemigatinib inhibits FGFR1–3 phosphorylation and signalling

Diagram showing the mechanism of action of pemigatinib

Reference:
PEMAZYRE® (pemigatinib). Summary of Product Characteristics. 2021.

Learn more about PEMAZYRE® (pemigatinib):

Targeted medicine

Discover about FGFR2 fusions in patients with CCA

Targeted medicine FGFR2 fusion testing
Histogram and magnifying glass

Learn about the efficacy of PEMAZYRE

Histogram and magnifying glass Efficacy
Shield and tick

Review the safety data of PEMAZYRE

Shield and tick Safety
Clock and pill

Understand the dosing and administration schedule for PEMAZYRE

Clock and pill Dosing and administration
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Coming soon

PEMAZYRE self-directed learning

A self-directed learning material on PEMAZYRE is available to complete in your own time. With the PEMAZYRE learning module, you can learn about the unmet needs in CCA, discuss the need for molecular profiling for early patient identification and learn more about PEMAZYRE.

Learn about PEMAZYRE

PEMAZYRE eDetail